Author

Charles P. Burton

Indiana University School of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Paul R. TerritoiD· 4 shared Scott A. PersohniD· 4 shared Ethan W. Miner· 3 shared Ravi S. PandeyiD· 3 shared Evgeny J. ChuminiD· 2 shared Gareth R. HowelliD· 2 shared Gregory W. CarteriD· 2 shared Kristen D. OnosiD· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Paul R. TerritoORCID

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Author profile →

4 papers

Recent·Most cited

Characterizing Molecular and Synaptic Signatures in Mouse Models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology

Kevin P. Kotredes, Ravi S. Pandey, Scott A. Persohn, Kierra Elderidge, Charles P. Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco da Silva dos Santos, Sean‐Paul Gerard Williams, Nicholas Heaton, Cynthia M. Ingraham, Christopher D Lloyd, Dylan T. Garceau, Rita O’Rourke, Sarah Herrick, , Adrian L. Oblak

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

Alzheimer s & Dementia · May 12, 2024Peer-reviewedNeuroscience

Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction

Kristen D. Onos, Peter Bor‐Chian Lin, Ravi S. Pandey, Scott A. Persohn, Charles P. Burton, Ethan W. Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E. Foley, Gregory W. Carter, Gareth R. Howell, Paul R. Territo

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

Alzheimer s & Dementia · May 7, 2024Peer-reviewedNeuroscience

Levetiracetam Modulates Brain Metabolic Networks and Transcriptomic Signatures in the 5XFAD Mouse Model of Alzheimer's disease.

Charles P. Burton, Evgeny J. Chumin, Alyssa Y. Collins, Scott A. Persohn, Kristen D. Onos, Ravi S. Pandey, Sara K. Quinney, Paul R. Territo

This study examines how levetiracetam affects brain metabolic networks and transcriptomic signatures in 5XFAD mice, showing dose- and sex-dependent changes in gene expression and cerebral metabolism.

Frontiers in Neuroscience · Jan 23, 2024Peer-reviewedNeuroscience

Brain Metabolic Network Covariance and Aging in a Mouse Model of Alzheimer's Disease

Evgeny J. Chumin, Charles P. Burton, Rebecca M. Silvola, Ethan W. Miner, Scott A. Persohn, Mattia Veronese, Paul R. Territo

The paper uses metabolic covariance analysis on PET imaging data from a mouse model of Alzheimer's disease to show age-related metabolic network changes and their alignment with clinical AD stages.

Alzheimer s & Dementia · Nov 30, 2023Peer-reviewedNeuroscience