Kristen D. Onos

The paper examines how genetic and tissue-specific factors influence the neuroinflammatory response to LPS in different brain regions of mice.

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

This study examines how levetiracetam affects brain metabolic networks and transcriptomic signatures in 5XFAD mice, showing dose- and sex-dependent changes in gene expression and cerebral metabolism.

This study shows that metabolic syndrome in NZO mice reduces microglial plasticity and increases vascular interactions compared to B6J mice.

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

The paper uses scRNA-seq to show genetic variation in microglia from different mouse strains affects their heterogeneity and response to amyloidosis in Alzheimer's disease models.