Author

Charles-Hugues Lardeau

Janssen (Belgium)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:benchmarking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Amy B. GoodaleiD· 2 shared Anne Elizabeth CarpenteriD· 2 shared Beth A. CiminiiD· 2 shared Bolek ZapieciD· 2 shared Briana Fritchman· 2 shared David GnuttiD· 2 shared David J. LoganiD· 2 shared Desiree Hernandez· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Amy B. GoodaleORCID

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Author profile →

4 papers

Recent·Most cited

Cell Painting-based bioactivity prediction boosts high-throughput screening hit-rates and compound diversity

Johan Fredin Haslum, Charles-Hugues Lardeau, Johan Karlsson, Riku Turkki, Karl‐Johan Leuchowius, Kevin Smith, Erik Müllers

This study uses deep learning on Cell Painting data to predict compound bioactivity, improving hit rates and diversity in high-throughput screening.

Nature Communications · Apr 24, 2024Peer-reviewedBioinformatics

Optimizing the Cell Painting assay for image-based profiling

Beth A. Cimini, Srinivas Niranj Chandrasekaran, Maria Kost‐Alimova, Lisa Miller, Amy B. Goodale, Briana Fritchman, Patrick J. Byrne, Sakshi Garg, Nasim Jamali, David J. Logan, John B. Concannon, Charles-Hugues Lardeau, Elizabeth Mouchet, Shantanu Singh, Hamdah Shafqat Abbasi, , Anne Elizabeth Carpenter

The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.

Nature Protocols · Jun 21, 2023Peer-reviewedBioinformatics

JUMP Cell Painting chemical dataset: Morphological map of 115,796 compounds in human cells

Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, Dale Michael Ando, John Arévalo, Melissa Bennion, Nicolas Boisseau, Adriana Borowa, Justin D. Boyd, Laurent Brino, Patrick J. Byrne, Hugo Ceulemans, Carolyn Ch’ng, Beth A. Cimini, Djork-Arné Clevert, , Anne Elizabeth Carpenter

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

bioRxiv · Mar 23, 2023 · PreprintBioinformatics✦ In-depth digest

Mapping the human kinome in response to DNA damage

Michel Owusu, Peter Bannauer, Joana Ferreira da Silva, Thanos P. Mourikis, A G Jones, Peter Májek, Michael Caldera, Marc Wiedner, Charles-Hugues Lardeau, André C. Müller, Jörg Menche, Stefan Kubicek, Francesca D. Ciccarelli, Joanna I. Loizou

The paper identifies kinase-specific vulnerabilities and resistances in response to DNA damaging agents using kinase-deficient cell lines and validates gene-drug interactions.

Cell Reports · Jan 1, 2019Peer-reviewedSystems Biology