Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Chien-Wen Chen, Bo‐Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya R. Bederman, , Maria Hatzoglou
This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.
Nature Communications · Aug 8, 2022Peer-reviewedSystems Biology