Thomas LaFramboise

The paper develops a multiplexed mouse model to study TBX2 subfamily and Egr1 roles in Ras-driven lung cancer, finding Egr1 loss significantly increases tumor size and suggests immune dysregulation.

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

This paper introduces a method called 3D-seq to map DNA-protein interaction sites in vivo using a modified cytosine deaminase, demonstrating its application in Pseudomonas aeruginosa transcription factors.