Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus
Tiegh Taylor, Natalia Sikorska, Virlana M. Shchuka, Sanjay Chahar, Chenfan Ji, Neil N. Macpherson, Sakthi D. Moorthy, Marit A. C. de Kort, Shanelle Mullany, Nawrah Khader, Zoe E. Gillespie, Lida Langroudi, Ian C. Tobias, Tineke Laura Lenstra, Jennifer A. Mitchell, Tom Sexton
The paper shows that transcriptional control and chromatin architecture at the Sox2 locus are decoupled, with distinct regulatory mechanisms.
Genes & Development · Jun 1, 2022Peer-reviewedGenetics