William M. Schneider

This study shows that HBV BCP mutations enhance viral replication and alter hepatocyte transcription, linking to specific HCC subtypes.

The paper develops CRISPR-Cas9 delivery methods for primary human hepatocytes to enable efficient gene editing and screening of HBV host factors.

The paper identifies HBV host factors using CRISPR screens and human liver chimeric mice, finding that EXOC1 is antiviral and ZCCHC14 is proviral.

This paper enhances the Eco1 retron editor for precise genome editing in human cells by improving ncRNA stability and reducing sgRNA extension, achieving editing without double-strand breaks.

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

The paper identifies TMEM41B as a host factor required for flavivirus infection and shows SNPs in TMEM41B reduce infection in East Asian populations.