CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreading
Yi Sun, Ruth A. Pumroy, Leena Mallik, Apala Chaudhuri, Chloe Wang, Daniel H. Hwang, Julia N. Danon, Kimia Dasteh Goli, Vera Y. Moiseenkova‐Bell, Nikolaos G. Sgourakis
The paper determines the cryo-EM structure of an MHC-I/TAPBPR peptide intermediate, revealing how antigen proofreading occurs through transient peptide interactions.
Proceedings of the National Academy of Sciences · Jan 9, 2025Peer-reviewedImmunology