TMEM Doorway Mediated Metastasis in Pancreatic Ductal Adenocarcinoma by Tie2 Signaling
Érika Pereira Zambalde, Lina A. Ariyan, Francisco Puerta-Martinez, Yu Quin Zhu, Priyanka Patil, Nicole C. Panarelli, Jiufeng Li, Yookyung Jung, Christian Adkisson, Jakeb S. S. M. Petersen, Dianne Cox, Hava Gil-Henn, Robert J. Eddy, Ben Z. Stanger, David R. Entenberg, , John C. McAuliffe
This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.
bioRxiv · Dec 9, 2025 · PreprintCancer Biology