Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes
Joanne E. Falck, Christine Bruns, Sheila Hoffmann-Conaway, Isabelle Straub, Erik J. Plautz, Marta Orlando, Humaira Munawar, Marion Rivalan, York Winter, Zsuzsanna Izsvák, Dietmar Schmitz, F. Kent Hamra, Stefan Hallermann, Craig Curtis Garner, Frauke Ackermann
This study shows that Piccolo knockout rats exhibit anatomical and behavioral features similar to Pontocerebellar Hypoplasia type 3, supporting a causal link between Piccolo function and PCH3.
Journal of Neuroscience · Mar 2, 2020Peer-reviewedNeuroscience