Marta Orlando

Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves

The paper investigates connectivity between thorny and athorny CA3 pyramidal neurons and finds asymmetric input patterns that may explain their sequential activation during sharp waves.

The synapsin-dependent vesicle cluster is crucial for presynaptic plasticity at a glutamatergic synapse in male mice

This study investigates the role of synapsin isoforms in presynaptic plasticity at hippocampal mossy fiber boutons in male mice, finding decreased short-term and increased long-term plasticity upon synapsin deletion.

Increased and synchronous recruitment of release sites underlies hippocampal mossy fiber presynaptic potentiation

The paper investigates presynaptic long-term potentiation in hippocampal mossy fibers, finding increased glutamate release surface area and structural remodeling without changes in calcium channel coupling.

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes

This study shows that Piccolo knockout rats exhibit anatomical and behavioral features similar to Pontocerebellar Hypoplasia type 3, supporting a causal link between Piccolo function and PCH3.

Light induced synaptic vesicle autophagy

This study uses light-induced ROS to control SV protein damage and shows that autophagy rapidly clears damaged proteins in mouse hippocampal neurons, maintaining synaptic function.