Zsuzsanna Izsvák

This study identifies HIF1A's role in recruiting primate-specific endogenous retroviruses into hypoxic and immune responses, revealing their regulatory impact on gene expression.

The paper identifies retroviral elements LTR8B and MER65 that regulate PSG9 expression, influencing trophoblast syncytialization and pre-eclampsia risk.

The paper investigates PGBD1's role in neuronal progenitor identity, stress sensing, and mammal-specific paraspeckles, showing its dual function in DNA binding and protein interaction.

The paper identifies a regulatory loop between MITF and HERV-K Rec that influences melanoma progression from proliferative to invasive stages.

This study identifies HMGXB4 as a regulator of Sleeping Beauty transposition in vertebrate germinal stem cells, linking it to chromatin dynamics and stemness maintenance during early development.

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

The paper identifies Pclo mutations in rats that affect reproductive behavior and link to depression-associated genes.

This study shows that Piccolo knockout rats exhibit anatomical and behavioral features similar to Pontocerebellar Hypoplasia type 3, supporting a causal link between Piccolo function and PCH3.

This study shows Piccolo is essential for synaptic vesicle recycling through Pra1 and Rab5, linking its dysfunction to neurological disorders.

The paper reanalyzes single-cell transcriptomic data and in situ stains to reveal the presence of a transcriptomically homologous inner cell mass in human blastocysts, highlighting unique developmental and evolutionary features.