PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function
Christine Bus, Sven Geisler, Marita Pauline Feldkaemper, Hector Flores‐Romero, Anna Schaedler, Katharina I. Zittlau, Maria Zarani, Betül Uysal, Nicolas Casadei, Petra Fallier‐Becker, Lisa Schwarz, Jos F.H.M. Brouwers, Henner Koch, Aslihan Ugun‐Klusek, Klaudia K. Maruszczak, , Julia Catherine Fitzgerald
This study identifies PINK1's role in regulating mitochondrial function, lipid metabolism, and dopamine homeostasis in dopaminergic neurons, showing that cholesterol depletion can reverse PINK1-related phenotypes.
bioRxiv · Oct 22, 2019 · PreprintNeuroscience