Author

Christine Gianfelice

Montreal Neurological Institute and Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexandre PratiD· 2 shared Aliyah ZamaniD· 2 shared Alyson E. FournieriD· 2 shared Elizabeth M.-L. HuaiD· 2 shared Jo Anne StrattoniD· 2 shared Kali Heale· 2 shared Sienna DrakeiD· 2 shared Stéphanie ZandeeiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alexandre PratORCID

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2 papers

Recent·Most cited

Cellular rejuvenation protects neurons from inflammation mediated cell death.

Sienna Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stéphanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

Cell Reports · Feb 1, 2025Peer-reviewedNeuroscience

Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitis.

Sienna Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klément, Jo Anne Stratton, Alexandre Prat, Stéphanie Zandee, Alyson E. Fournier

This study shows that senolytic treatment reduces microglia and alleviates EAE symptoms in mice, suggesting senescent glia contribute to neuroinflammation.

Journal of Neuroinflammation · Nov 1, 2024Peer-reviewedNeuroscience