Adam M.R. Groh

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

The paper identifies Myocilin as a marker for glia limitans superficialis astrocytes in mouse and human, showing their specialized morphology and evolutionary conservation.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

This study finds that patients with primary ciliary dyskinesia show increased ventriculomegaly and age-related ventricular enlargement, potentially linked to ependymal ciliary dysfunction.

The paper uses multiomic single nucleus RNA/ATAC sequencing to show ependymal cell dysregulation correlates with periventricular pathology in MS and identifies IFNγ as a driver.

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

This study creates the first layer-resolved atlas of the adult human meninges using single-cell RNA sequencing, MERFISH, and immunolabeling, identifying 10 fibroblast subpopulations and novel interactions in the dura and subarachnoid space.