Alice Mann

Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases

This study uses regulatory QTLs from immune cells to fine-map causal variants for twelve immune-mediated diseases, finding smaller credible sets and higher posterior probabilities compared to traditional methods.

Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets

The paper identifies immune disease variants affecting Treg gene expression and highlights potential drug targets by linking GWAS signals with Treg QTLs.

Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility

The paper identifies how variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility and cell count differences.

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune response

The paper identifies genetic effects on chromatin and gene expression in immune response conditions, revealing enhancer priming in naive cells.

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell Types

The paper measures and compares transcriptional and epigenetic variability across immune cell types and finds neutrophils exhibit higher variability linked to immune pathways and environmental exposure.