Gordon Dougan

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

This paper introduces RGStraP, a tool to infer genetic population structure from RNAseq data and shows it can control for population structure in gene expression analyses.

The paper analyzes S. Paratyphi A isolates to show genome degradation and gene flux drive lineage evolution, with implications for public health surveillance.

This study characterizes the genomic structure and evolutionary history of Salmonella Typhi in Samoa, revealing dominant rare genotypes with low antimicrobial resistance.

The paper introduces Pathogenwatch, a tool for genomic surveillance of Salmonella Typhi, enabling AMR prediction and population-level risk assessment through global data sharing.

The paper generates high-quality reference genomes for seven major ETEC lineages using long-read sequencing, revealing conserved virulence plasmids crucial for pathogenesis.

This study investigates the genomic epidemiology of multi-drug resistant nontyphoidal Salmonella in sub-Saharan Africa, identifying key serotypes and transmission patterns.

The paper describes the development of a validated SARS-CoV-2 diagnostic workflow in an academic laboratory to support local screening during the pandemic.

This paper analyzes Salmonella Typhi isolates from Bangladesh 2004-2016 to identify population structure and antimicrobial resistance patterns, finding a decline in H58 genotypes and rise in non-H58 genotypes with fluoroquinolone resistance.

The paper identifies a host gene signature using machine learning to distinguish enteric fever from other febrile diseases with high accuracy.

The paper analyzes ESBL-producing Klebsiella strains to show dynamic resistance evolution and highlights that successful lineages are not necessarily the most resistant or virulent.

The paper identifies over 16,000 secreted proteins in Legionella species, revealing their ability to acquire eukaryotic-like genes for intracellular replication in human cells.

This study analyzes Salmonella isolates from Nepali children to assess antimicrobial resistance and inform vaccine policy.

PlasmidTron identifies mobile genetic elements linked to phenotypes by analyzing short read WGS data and phenotypic metadata from bacterial populations.

The paper identifies genetic effects on chromatin and gene expression in immune response conditions, revealing enhancer priming in naive cells.

The paper compares transcriptomes of macrophages derived from monocytes and iPSCs to identify conserved and novel LPS responses.