Author

Patrick J. Pagano

University of PittsburghORCID 0000-0002-7475-808XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Alevtina Zharikov· 1 shared Christopher R. Bodle· 1 shared Edward A. BurtoniD· 1 shared Eric K. HoffmaniD· 1 shared Eugenia Cifuentes-PaganoiD· 1 shared Evan DeVallanceiD· 1 shared Feng LiiD· 1 shared Hridyanshu Vyas· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alevtina Zharikov

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2 papers

Recent·Most cited

TEAD1 is a novel regulator of NRF2 and oxidative stress response in cardiomyocytes

Rajaganapathi Jagannathan, Jeongkyung Lee, Evan DeVallance, Vinny Negi, Varun Mandi, Hridyanshu Vyas, Feng Li, Patrick J. Pagano, Vijay K. Yechoor, Mousumi Moulik

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

bioRxiv · Apr 6, 2025 · PreprintMolecular Biology

Neuronal NADPH oxidase in Parkinson disease pathogenesis

Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio

The paper demonstrates that neuronal NOX2 contributes to oxidative stress, α-synuclein pathology, and LRRK2 activation in Parkinson's disease and shows that NOX2 inhibitors can prevent these effects in a rat model.

bioRxiv · May 13, 2021 · PreprintNeuroscience