Author

Christos Chatzinakos

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Brien P. RileyiD· 2 shared Hüseyin GedikiD· 2 shared Nikolaos P. DaskalakisiD· 2 shared Roseann Elizabeth PetersoniD· 2 shared Silviu‐Alin BacanuiD· 2 shared Vladimir I. VladimiroviD· 2 shared Alexander GuseviD· 1 shared Amber R. Curry· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Brien P. RileyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

Dominic Kaul, Amber R. Curry, Nathalie Gerstner, Anna Sophie Fröhlich, Anthi C Krontira, Christina Kyrousi, Caine C. Smith, Greg Trevor Sutherland, Mirella Dottori, Michael J. Ziller, Christos Chatzinakos, Nikolaos P Daskalakis, Silvia Cappello, Darina Czamara, Elisabeth B. Binder, , Natalie Matosin

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

bioRxiv · Jun 24, 2024 · PreprintNeuroscience

A novel multi-omics mendelian randomization method for gene set enrichment and its application to psychiatric disorders

Hüseyin Gedik, Roseann Elizabeth Peterson, Christos Chatzinakos, Mikhail G. Dozmorov, Vladimir I. Vladimirov, Brien P. Riley, Silviu‐Alin Bacanu

This paper introduces MR-GSE, a multi-omics Mendelian randomization method for gene set enrichment in psychiatric disorders, showing increased detection of significant gene sets compared to non-MR methods.

medRxiv · Apr 14, 2024 · PreprintGenetic & Genomic Medicine

Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information

Hüseyin Gedik, Tan Hoang Nguyen, Roseann Elizabeth Peterson, Christos Chatzinakos, Brien P. Riley, Vladimir I. Vladimirov, Silviu‐Alin Bacanu

This paper identifies risk genes and pathways for neuropsychiatric and substance use disorders using XWAS analyses in blood and brain tissues, finding shared signals in the MHC region and other genomic areas.

Frontiers in Genetics · Jun 21, 2023Peer-reviewedGenetic & Genomic Medicine

Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain

Cindy H. Wen, Michael P. Margolis, Rujia Dai, Pan Zhang, Pawel F. Przytycki, Daniel Vo, Arujun Bhattacharya, Minsoo Kim, Nana Matoba, Ellen A. Tsai, Celine Hoh, Chuan Jiao, Nil Aygün, Rebecca L. Walker, Christos Chatzinakos, , Michael J. Gandal

The paper constructs a cross-ancestry, cell-type-informed gene regulatory atlas of the developing human brain, identifying genetic regulation and linking it to neuropsychiatric disorders.

medRxiv · Mar 3, 2023 · PreprintGenetic & Genomic Medicine