Author

Sharmistha Pal

Dana-Farber Cancer InstituteORCID 0000-0001-5391-5149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrew P. StoneiD· 1 shared Charles Stiles· 1 shared Christopher J. GraseriD· 1 shared Clementine Payne· 1 shared Daphne Adele Haas-KoganiD· 1 shared Dipanjan ChowdhuryiD· 1 shared Dong Hoon LeeiD· 1 shared Estelle CarminitaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Andrew P. StoneORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 15, 2026

H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas

Sharmistha Pal, Heng Wang, Jacob Geisberg…·Daphne Adele Haas-Kogan

This study identifies hypertranscription as a vulnerability in H3K27M-driven diffuse midline gliomas, showing ATR inhibition effectively targets this feature in preclinical models.

DOI 10.64898/2026.05.12.724628

mousehuman

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Cell BiologybioRxivPreprintMay 8, 2025

Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production

Roelof Hendrik Bekendam, Virginia Camacho, Andrew P. Stone…·Kellie R. Machlus

The paper shows that low-dose PARP inhibitors or gamma-irradiation increase DNA damage in megakaryocytes and their progenitors, leading to higher megakaryopoiesis and platelet production in mice.

DOI 10.1101/2025.05.08.652525

mouseATAC-seq

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