Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST
Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun, Jonathan G. Van Vranken, Sebastian Schindler, Abhilash Jayaraj, Sumeet A. Khetarpal, Ariana Vargas‐Castillo, Anna M. Puszynska, Jessica B. Spinelli, Andrea Armani, Tenzin Kunchok, Birgitta A. Ryback, Hyuk‐Soo Seo, Kijun Song, , Bruce M. Spiegelman
This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.
bioRxiv · Apr 10, 2024 · PreprintMolecular Biology