Lan Wang

Inherited retinal degenerations: PARP regulates calpain activation via TRPM2 channels in rd1 mouse photoreceptors

This study investigates how PARP regulates calpain activity in rd1 mouse photoreceptors and identifies potential therapeutic targets for inherited retinal degenerations.

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

Resolving the estrogen paradox in hereditary retinal degeneration: Esr1 activation suppresses Tnf-α signaling as a photoreceptor self-protection mechanism

This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.

Inherited retinal degeneration: T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death.

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

Single-cell transcriptomic profiling in inherited retinal degen-eration reveals distinct metabolic pathways in rod and cone photoreceptors

This study uses scRNA-seq to analyze metabolic changes in mouse retinal cells during degeneration, identifying Ca2+-signaling and MAPK pathway involvement.

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

The paper shows how a point mutation in eIF2B's β subunit mimics eIF2-P binding, leading to constitutive activation of the integrated stress response through an I-State conformation.