Interneuron theta phase locking controls seizure susceptibility
Zoé Christenson Wick, Paul A. Philipsberg, Cassidy Kohler, Sophia I. Lamsifer, Elizabeth Katanov, Christopher D. Adam, Kathryn E Gordon, Yu Feng, Lauren M. Vetere, Genevra C Donnelly, Corin Humphrey, Denise J. Cai, Tristan Shuman
This study demonstrates that inhibitory theta phase locking in interneurons directly controls seizure susceptibility using a closed-loop optogenetic system.
bioRxiv · Sep 10, 2025 · PreprintNeuroscience