Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis
Miguel Ángel López-Unzu, María Rosaria Pricolo, Roberto Silva‐Rojas, Alejandro Clemente-Manteca, David Sánchez-Ortiz, Natalia Vicente, Diana Velázquez-Carreras, Cristina Morales, Manuel Gavilán-Herrera, Laura Sen-Martín, Ángel Fernández‐Trasancos, Verónica Labrador-Cantarero, Lucía Sánchez-García, Carlos Relaño‐Rupérez, Fátima Sánchez‐Cabo, , Jorge Alegre‐Cebollada
This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.
bioRxiv · Apr 22, 2025 · PreprintPhysiology