Diana Velázquez-Carreras

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

Pathological stiffening by crosslinking glycation of titin

This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.