Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR
Chengming He, Nikhil R. Varghese, Eric G. Keeler, Chi L.L. Pham, Teng Xie, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L. Wilde, Simon H. J. Brown, James C. Bouwer, Yann Gambin, Emma Sierecki, Megan C. Steain, Ruhong Zhou, , Ann E. McDermott
This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.
Proceedings of the National Academy of Sciences · Apr 27, 2026Peer-reviewedBiophysics