Author
S. J. Forbes
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 6 mutual co-author links8 papers
Recent·Most cited
Utilising an in silico model to predict outcomes in senescence-driven acute liver injury
C. Ashmore-Harris, E. Antonopoulou, R. E. Aird, T. Y. Man, S. M. Finney, A. Speel, W.-Y. Lu, S. J. Forbes, V. L. Gadd, S. L. Waters
The paper develops an in silico model to predict host responses to varying degrees of liver injury and validates it against experimental data in mice.
bioRxiv · Oct 11, 2023Cell Biology
MC1R reduces scarring and rescues stalled healing in a preclinical chronic wound model
Y. Nawilaijaroen, H. R. Rocliffe, S. Austin-Williams, G. Krilis, A. Pellicoro, K. Zhou, Y. Ji, C. Bain, A. M. Kilpatrick, Y. Chen, M. Crichton, Z. Huang, S. J. Forbes, A. Caporali, J. L. Cash
This study shows that MC1R agonist reduces scarring and improves healing in a chronic wound model by enhancing angiogenesis, lymphangiogenesis, and reducing inflammation.
bioRxiv · Nov 30, 2022 · PreprintPathology
Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
R. Carlessi, E. Denisenko, E. Boslem, J. Koehn-Gaone, N. Main, N. D. B. A. Bakar, G. D. Shirolkar, M. Jones, D. Poppe, B. J. Dwyer, C. Jackaman, M. C. Tjiam, R. Lister, M. Karin, J. A. Fallowfield, , J. E. E. Tirnitz-Parker
The paper uses snRNA-seq to identify a disease-associated hepatocyte state in pre-malignant livers that correlates with HCC risk in mice and humans.
bioRxiv · Mar 25, 2022Cancer Biology
Serum CSF1 levels are elevated in patients following partial hepatectomy and acetaminophen induced acute liver failure: Reanalysis of previous data
B. Stutchfield, P. Starkey Lewis, S. Wigmore, K. Simpson, D. A. Hume, S. J. Forbes
This study reanalyzes previous data showing elevated serum CSF1 levels after partial hepatectomy and in ALF patients, with higher levels in non-survivors.
bioRxiv · Apr 2, 2021 · PreprintImmunology
Recruited macrophages that colonise the post-inflammatory peritoneal niche convert into functionally divergent resident cells
P. A. Louwe, L. Badiola-Gomez, H. Webster, G. Perona-Wright, C. C. Bain, S. J. Forbes, S. J. Jenkins
This study shows inflammation-elicited macrophages in the peritoneal cavity can adopt a resident-like identity but are functionally divergent due to environmental influences and time of residency.
bioRxiv · Nov 30, 2020Immunology
Canonical Wnt signalling is activated during BEC-to-hepatocyte conversion in vivo and modulates liver epithelial cell plasticity in hepatic organoids
E. Valle-Encinas, N. Aleksieva, C. Velasco Martinez, M. Dawes, M. Zverev, M. Muller, A. Offergeld, M. J. Smalley, C. Hogan, S. J. Forbes, T. G. Bird, T. C. Dale
This study investigates the role of canonical Wnt signaling in BEC-to-hepatocyte conversion during liver injury and shows its impact on epithelial cell plasticity in hepatic organoids.
bioRxiv · Nov 9, 2020 · PreprintCell Biology
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose
D. Laurent, F. Semple, P. J. Starkey Lewis, E. Rose, H. A. Black, S. J. Forbes, M. J. Arends, J. W. Dear, T. J. Aitman
This study directly measures the tissue origins of cell-free DNA in healthy mice and after paracetamol overdose, showing increased liver contribution in cases of liver injury.
bioRxiv · Jul 26, 2019Pharmacology & Toxicology