Author

D. A. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

N. Chakravarti· 2 shared A. A. Gingrich· 1 shared A. B. L. Colamartino· 1 shared A. C. Gross· 1 shared A. M. Glaspell· 1 shared A. M. Monjazeb· 1 shared A. Näätänen· 1 shared B. Ghimire· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersImmunology

N. Chakravarti

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

E. M. Ringwalt, M. A. Currier, A. M. Glaspell, C.-Y. Chen, M. V. Cannon, M. Cam, A. C. Gross, M. Gust, P.-Y. Wang, L. Boon, L. E. Biederman, E. Schwarz, P. Rajappa, D. A. Lee, E. R. Mardis, , T. P. Cripe

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

bioRxiv · Mar 2, 2024Cancer Biology

Single-cell functional genomics of natural killer cell evasion in blood cancers

O. Dufva, S. Gandolfi, J. Huuhtanen, O. Dashevsky, K. Saeed, J. Klievink, P. Nygren, J. Bouhlal, J. Lahtela, A. Näätänen, B. Ghimire, T. Hannunen, P. Ellonen, H. Duan, J. Theodoropoulos, , S. Mustjoki

The paper uses single-cell and genome-scale functional genomics to study how blood cancer cells evade NK cells, identifying key genes and pathways involved in resistance and sensitivity.

bioRxiv · Aug 22, 2022 · PreprintImmunology

CRISPR-Targeted CAR Gene Insertion Using Cas9/RNP and AAV6 Enhances Anti-AML Activity of Primary NK Cells

M. Naeimi Kararoudi, S. Likhite, E. Elmas, K. Yamamoto, M. Schwartz, K. Sorathia, M. Pereira, R. Devine, J. Lyberger, G. K. Behbehani, N. Chakravarti, B. K. Moriarity, K. Meyer, D. A. Lee

bioRxiv · Mar 17, 2021 · PreprintImmunology

Blood and Tissue Biomarker Analysis in Dogs with Osteosarcoma Treated with Palliative Radiation and Intra-Tumoral Autologous Natural Killer Cell Transfer

R. Canter, S. J. Judge, M. Yanagisawa, I. R. Sturgill, S. B. Bateni, A. A. Gingrich, J. A. Foltz, D. A. Lee, J. F. Modiano, A. M. Monjazeb, W. T. N. Culp, R. B. Rebhun, W. J. Murphy, M. S. Kent

The paper analyzes blood and tissue biomarkers in dogs with osteosarcoma treated with radiation and NK cell therapy, finding correlations between immune markers and survival.

bioRxiv · Oct 23, 2019Immunology

Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)

C. P. Bailey, M. M. Romero, O. J. Becher, M. Monje, D. A. Lee, L. Wang, J. Chandra

This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.

bioRxiv · Jul 2, 2019 · PreprintCancer Biology

Efficient and robust NK-Cell transduction with Baboon Envelope pseudotyped lentivector: a major tool for immunotherapy

A. B. L. Colamartino, W. Lemieux, P. Bifsha, S. Nicoletti, N. Chakravarti, J. S. Remon, H. Romero, S. Selleri, K. Beland, M. Guiot, C. Tremblay-Laganiere, R. Dicaire, L. Barreiro, D. A. Lee, E. Verhoeyen, E. Haddad

This paper demonstrates that Baboon Envelope pseudotyped lentiviral vectors efficiently transduce NK-cells, enabling CAR expression and specific killing of cancer cell lines.

bioRxiv · May 2, 2019Immunology