Author

O. J. Becher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

D. G. Kirsch· 3 shared K. Deland· 3 shared L. Luo· 3 shared N. T. Williams· 3 shared C. E. Stewart· 2 shared J. A. Regal· 2 shared M. E. Guerra Garcia· 2 shared Y. Ma· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

D. G. Kirsch

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Author profile →

4 papers

Recent·Most cited

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

A. Mangoli, S. Wu, H. Q. Liu, M. Aksu, V. J. Jain, B. E. Foreman, J. A. Regal, L. B. Weidenhammer, C. E. Stewart, M. E. Guerra Garcia, E. Hocke, K. Abramson, N. T. Williams, L. Luo, K. Deland, , Z. J. Reitman

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

bioRxiv · Oct 18, 2023Cancer Biology

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

C. E. Stewart, M. E. Guerra Garcia, L. Luo, N. T. Williams, Y. Ma, J. A. Regal, D. Ghosh, P. Sansone, M. Oldham, K. Deland, O. J. Becher, D. G. Kirsch, Z. J. Reitman

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

bioRxiv · Aug 5, 2022Cancer Biology

Tumor genotype dictates radiosensitization after Atm deletion in brainstem gliomas

K. Deland, B. F. Starr, J. S. Mercer, J. Byemerwa, D. M. Crabtree, N. T. Williams, L. Luo, Y. Ma, M. Chen, O. J. Becher, D. G. Kirsch

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.

bioRxiv · Aug 24, 2020Cancer Biology

Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)

C. P. Bailey, M. M. Romero, O. J. Becher, M. Monje, D. A. Lee, L. Wang, J. Chandra

This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.

bioRxiv · Jul 2, 2019 · PreprintCancer Biology