Author

M. D. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Organism:virus· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. B. Lindsey· 2 shared COVID-19 Genomics UK (COG-UK) Consortium· 2 shared H. Huang· 2 shared K. Karbstein· 2 shared S. L. Rowland-Jones· 2 shared T. I. de Silva· 2 shared A. Angyal· 1 shared A. Chopra· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

B. B. Lindsey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase activity in 40S ribosome assembly

H. Huang, M. D. Parker, K. Karbstein

This study shows that Tsr3 establishes a hierarchy between Rio2 and Rio1 kinases during 40S ribosome assembly by preventing Rio2 rebinding and enabling Rio1 recruitment.

bioRxiv · Sep 28, 2021 · PreprintBiochemistry

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

T. I. de Silva, G. Liu, B. B. Lindsey, D. Dong, D. Shah, A. J. Mentzer, A. Angyal, R. Brown, M. D. Parker, Z. Yin, X. Yao, L. Turtle, S. Dunachie, COVID-19 Genomics UK (COG-UK) Consortium, M. K. Maini, , T. Dong

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

bioRxiv · Apr 8, 2021Immunology

An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7

J. Rai, M. D. Parker, H. Huang, S. Choi, H. Ghalei, M. C. Johnson, K. Karbstein, M. E. Stroupe

The paper determines the structure of an 80S-like ribosome assembly intermediate, revealing how Tsr1 and Dim1 coordinate to regulate Fap7 and enable quality control during ribosome maturation.

bioRxiv · Oct 26, 2020 · PreprintBiochemistry

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B. Korber, W. Fischer, S. G. Gnanakaran, H. Yoon, J. Theiler, W. Abfalterer, B. Foley, E. E. Giorgi, T. Bhattacharya, M. D. Parker, D. G. Partridge, C. M. Evans, T. de Silva, C. C. LaBranche, D. C. Montefiori, Sheffield COVID-19 Genomics Group

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

bioRxiv · Apr 29, 2020Evolutionary Biology

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

S. Leary, S. Gaudieri, M. D. Parker, A. Chopra, I. James, S. Pakala, E. Alves, M. John, B. B. Lindsey, A. J. Keeley, S. L. Rowland-Jones, M. Swanson, D. A. Ostrov, J. L. Bubenik, S. Das, , S. Mallal

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

bioRxiv · Apr 10, 2020 · PreprintMicrobiology