Author

D. B. Wilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:virus· 1

Frequent Co-Authors

O. Dushek· 3 shared P. A. van der Merwe· 3 shared A. Huhn· 2 shared E. Abu-Shah· 2 shared J. Pettmann· 2 shared M. A. Kutuzov· 2 shared M. Dustin· 2 shared S. Davis· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

O. Dushek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

A. Huhn, D. A. Nissley, D. B. Wilson, M. A. Kutuzov, R. Donat, T. K. Tan, Y. Zhang, M. I. Barton, C. Liu, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, A. Townsend, W. S. James, G. Screaton, , O. Dushek

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

bioRxiv · Sep 6, 2023 · PreprintImmunology

Genetic diversity in facultatively sexual populations and its implications for the origins of self-incompatibility in algae and fungi

A. S. A. Smith, S. Penington, I. Letter, D. B. Wilson, G. W. A. Constable

The paper mathematically analyzes how self-incompatibility affects mating probabilities and genetic diversity in facultatively sexual populations, showing its potential evolutionary advantages.

bioRxiv · Apr 4, 2021 · PreprintEvolutionary Biology

The discriminatory power of the T cell receptor

J. Pettmann, A. Huhn, E. Abu-Shah, M. A. Kutuzov, D. B. Wilson, M. Dustin, S. Davis, P. A. van der Merwe, O. Dushek

This study measures TCR discriminatory power against pMHC antigens and finds it is imperfect, with T cells responding to low-affinity self pMHC with KD ~1 mM.

bioRxiv · Nov 16, 2020Immunology

T cells exhibit unexpectedly low discriminatory power and can respond to ultra-low affinity peptide-MHC ligands

J. Pettmann, E. Abu-Shah, M. Kutuzov, D. B. Wilson, M. Dustin, S. Davis, P. A. van der Merwe, O. Dushek

The paper measures ultra-low TCR/pMHC affinities and finds T cells have low discriminatory power, requiring large affinity differences to trigger responses.

bioRxiv · Nov 14, 2020 · PreprintImmunology