Author

M. I. Barton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. A. van der Merwe· 5 shared E. M. Denham· 3 shared O. Dushek· 3 shared J. Goyette· 2 shared M. A. Kutuzov· 2 shared R. L. Paterson· 2 shared A. Huhn· 1 shared A. M. Morch· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersImmunology

P. A. van der Merwe

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Author profile →

5 papers

Recent·Most cited

Ligand requirements for immunoreceptor triggering

M. I. Barton, R. L. Paterson, E. M. Denham, J. Goyette, P. A. van der Merwe

This study investigates ligand requirements for NTR triggering by varying ligand length, mobility, and valency, finding that size-based segregation, not clustering or mechanical force, is more consistent with the kinetic-segregation model.

bioRxiv · Sep 11, 2023Immunology

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

A. Huhn, D. A. Nissley, D. B. Wilson, M. A. Kutuzov, R. Donat, T. K. Tan, Y. Zhang, M. I. Barton, C. Liu, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, A. Townsend, W. S. James, G. Screaton, , O. Dushek

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

bioRxiv · Sep 6, 2023 · PreprintImmunology

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

A. Patel, V. Andre, S. Bustamante Eguiguren, M. I. Barton, J. Burton, E. M. Denham, J. Pettmann, A. M. Morch, M. Kutuzov, J. A. Siller-Farfan, M. L. Dustin, P. A. van der Merwe, O. Dushek

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

bioRxiv · Jun 15, 2023 · PreprintImmunology

Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics

M. I. Barton, S. MacGowan, M. A. Kutuzov, O. Dushek, G. J. Barton, P. A. van der Merwe

This study analyzes how common mutations in SARS-CoV-2 Spike RBD and human ACE2 affect binding affinity and kinetics, identifying their roles in transmission and immune escape.

bioRxiv · May 18, 2021Microbiology

A generic cell surface ligand system for studying cell-cell recognition

E. M. Denham, M. I. Barton, S. M. Black, M. J. Bridge, B. de Wet, R. L. Paterson, P. A. van der Merwe, J. Goyette

This paper introduces a generic cell surface ligand system to manipulate ligand density, valency, dimensions, and affinity for studying cell-cell recognition.

bioRxiv · Feb 11, 2019Immunology