D. A. Nissley

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

The paper profiles T-cell receptor-mimetic antibodies (TCRms) against pMHC complexes to quantify their TCR-likeness and identify molecular differences in antigen recognition.

Synonymous mutations can alter protein dimerization through localized interface misfolding involving self-entanglements

This paper shows synonymous mutations can alter protein dimerization by causing misfolded self-entangled states that disrupt dimer interfaces, with effects dependent on translation speed.

Subpopulations of soluble, misfolded proteins commonly bypass chaperones: How it happens at the molecular level

The paper shows that some soluble, misfolded proteins evade chaperones by being structurally similar to native states, leading to long-term misfolding.

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less-functional

The paper shows that misfolded proteins can bypass proteostasis by being structurally similar to native states and persisting for long periods.

Domain topology, stability, and translation speed determine mechanical force generation on the ribosome

This study shows that mechanical forces on ribosomes during translation depend on domain stability, topology, and translation speed, with implications for protein structure and evolution.