D. Cacchiarelli

Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic and tracheal fluids.

The paper derives epithelial organoids from human amniotic and tracheal fluids to model congenital malformations and predict disease outcomes.

Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function.

This study shows that decellularized skeletal muscle ECM guides hiPSC differentiation into structured neuromuscular organoids with functional neuromuscular junctions and disease-mimicking contractility.

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

This study identifies shared host dependency factors across multiple SARS-CoV-2 variants and shows antioxidant drugs are effective against all tested variants.

SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids

This paper shows that SARS-CoV-2 can infect and replicate in pediatric gastric organoids but not in fetal ones, suggesting differential susceptibility based on developmental stage.

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancer

This study identifies DNA methylation differences between fimbrial and ovarian surface epithelia to create an epigenetic tracer that stratifies high grade serous ovarian cancer into clinically distinct subtypes with prognostic significance.