P. De Coppi

Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic and tracheal fluids.

The paper derives epithelial organoids from human amniotic and tracheal fluids to model congenital malformations and predict disease outcomes.

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

Lung viral infection modelling in a bioengineered whole-organ

This paper develops a bioreactor-based whole-organ lung model to study viral infections and demonstrates its use for testing antiviral drugs like Remdesivir.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry

This study shows that neuroepithelial cells synchronize apical constriction with cell cycle progression, but the timing of constriction is influenced by tissue geometry in different regions of the neural tube.

SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids

This paper shows that SARS-CoV-2 can infect and replicate in pediatric gastric organoids but not in fetal ones, suggesting differential susceptibility based on developmental stage.

Cell-intrinsic differences between human airway epithelial cells from children and adults

The paper compares airway epithelial cells from children and adults, finding intrinsic differences in transcriptional profiles and regenerative capacity.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.