W. Qin

Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System

This paper identifies TseP as a dual amidase-lysozyme T6SS effector with potential for combating antimicrobial resistance.

Metabolites reflect variability introduced by mesoscale eddies in the North Pacific Subtropical Gyre

This study examines how mesoscale eddies affect the metabolome of the North Pacific Subtropical Gyre by analyzing metabolite concentrations and molecular features across different eddy states.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

The 3D ultrastructural morphology of a marine ammonia-oxidizing archaeon

This study uses cryo-ET and STEM-EDS to reveal the ultrastructural morphology and elemental composition of Nitrosopumilus maritimus SCM1, identifying two types of storage granules.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

The diversity and ecological significance of microbial traits potentially involved in B12 biosynthesis in the global ocean

This study examines microbial traits involved in B12 biosynthesis in the global ocean, revealing that environmental factors select functional traits over taxonomy and that functional redundancy drives community assembly.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function.

This study shows that decellularized skeletal muscle ECM guides hiPSC differentiation into structured neuromuscular organoids with functional neuromuscular junctions and disease-mimicking contractility.

An intact amber-free HIV-1 system for in-virus protein bioorthogonal click labeling that delineates envelope conformational dynamics

This paper develops an amber-free HIV-1 system for in-virus protein labeling, enabling smFRET analysis of Env conformational dynamics without disrupting structural integrity.

MicroRNA-195-3p as a potential regulator of hypoxic injury in HUVECs

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

A novel order-level lineage of ammonia-oxidizing Thaumarchaeota is widespread in marine and terrestrial environments

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

Dynamic mapping of proteome trafficking within and between living cells by TransitID

TransitID maps proteome trafficking between cellular compartments and between cells with nanometer resolution, revealing new roles for stress granules and intercellular signaling.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

Characterization of N distribution in different organs of winter wheat using UAV-based remote sensing

This study evaluates UAV-based remote sensing for predicting nitrogen content and nitrogen agronomic efficiency in winter wheat organs using vegetation indices and texture features.

Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger

This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

Probing protein ubiquitination in live cells

This paper introduces a fluorescent assay to detect protein ubiquitination in live cells and identifies new targets and regulators of this process.

Alpha cell dysfunction in early type 1 diabetes

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

Marine community metabolomes carry fingerprints of phytoplankton community composition

The paper shows that marine community metabolomes reflect phytoplankton community composition and highlights understudied compounds that represent significant pools of labile carbon.

Fusobacterium nucleatum facilitates cetuximab resistance in colorectal cancer via the PI3K/AKT and JAK/STAT3 pathways

A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.

Light quality signals generated by vegetation shade facilitate acclimation to reduced light quantity in shade-avoider plants

This study shows that low R:FR light signals help shade-avoider plants improve their photoacclimation to reduced light quantity by triggering molecular and developmental changes.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Differential urine proteome analysis of a bovine IRBP induced uveitis rat model by discovery and parallel reaction monitoring proteomics

This study identifies urinary protein biomarkers for uveitis using DIA and PRM proteomics in an EAU rat model, finding 12 proteins significantly altered before clinical symptoms.

Multi-Region Brain Stimulation Optimization Using Transcranial Direct Current Stimulation

This study evaluates two tDCS optimization schemes for single and multi-target brain stimulation, showing that parameter settings significantly affect outcomes, especially in multi-target cases, and proposes improved weighted schemes.

Early urine proteome changes in an implanted bone cancer rat model

This study identifies early urine proteome changes in a bone cancer rat model, detecting significant protein alterations before CT-identified lesions.

A Dry Method For Preserving Tear Samples

This paper introduces a dry method for preserving tear samples using Schirmers strips and vacuum bags, enabling room temperature storage and protein pattern preservation comparable to traditional wet methods.