Author

D. Crossman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Yamashita· 2 shared H. Kornblum· 2 shared I. Nakano· 2 shared M. A. Nakano· 2 shared M. Gorospe· 2 shared S. Ozaki· 2 shared S. Yamaguchi· 2 shared T. Kondo· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

D. Yamashita

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

D. Yamashita, D. Botta, H. J. Cho, X. Guo, S. Ozaki, V. L. Flanary, I. Sirota, M. Gao, S. Yamaguchi, M. A. Nakano, F. Zhou, H. Zhou, T. Kondo, T. Kunieda, D. Crossman, , I. Nakano

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

D. Yamashita, V. L. Flanary, R. B. Munk, K. Sonomura, S. Ozaki, R. Kawaguchi, S. Suehiro, S. Bastola, M. S. Pavlyukov, S. Yamaguchi, M. A. Nakano, T. Kunieda, D. Hambardzumyan, T. Kondo, H. Kornblum, , I. Nakano

This study shows that aging reduces neuronal signaling in gliomas, but NAD+ and BDNF can reverse these effects, improving outcomes in older mice.

bioRxiv · Oct 10, 2020 · PreprintCancer Biology

Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency

K. Hu, L. Ianov, D. Crossman

This paper defines the reprogramome as the full set of genes reprogrammed to pluripotency and quantifies reprogramming using a mathematical model, revealing key pathways involved in fibroblast reprogramming to PSCs.

bioRxiv · Feb 25, 2020 · PreprintCell Biology

Impaired Regulation of Redox Transcriptome during the Differentiation of iPSCs into Induced Cardiomyocytes (iCMs)

G. Shanmugam, D. Crossman, J. Rajasingh, B. Dalley, J. Zhang, R. Namakkal-Soorappan

The paper analyzes transcriptome changes during iPSC differentiation into iCMs and identifies impaired redox signaling and mitochondrial functions as critical factors affecting cell survival and cardiac regeneration.

bioRxiv · Jan 14, 2019 · PreprintCell Biology