Author

H. Kornblum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:bulk RNA-seq· 6 Research Focus:cancer & tumor microenvironment· 6 Organism:human· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3

Frequent Co-Authors

I. Nakano· 4 shared R. Kawaguchi· 4 shared D. Yamashita· 3 shared M. A. Nakano· 3 shared M. Condro· 3 shared S. Bastola· 3 shared Y. Qin· 3 shared A. Sohrabi· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

I. Nakano

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma

L. S. Elahi, M. Condro, R. Kawaguchi, Y. Qin, A. G. Alvarado, B. Gruender, H. Stewart, T. Li, A. Lai, M. Garrett, M. Castro, P. R. Lowenstein, H. Kornblum

This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.

bioRxiv · Nov 15, 2023Cancer Biology

NADPH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent manner

K. Ludwig, J. Le Belle, S. D. D. Muthukrishnan, J. Sperry, M. Condro, E. Vlashi, F. Pajonk, H. Kornblum

This study shows that NADPH oxidase promotes glioblastoma radiation resistance through PTEN-dependent ROS production and Akt activation.

bioRxiv · Jun 16, 2022Cancer Biology

Canonical BMP2/4 signaling degrades SOX2 in glioblastoma propagating cells.

F. Comadamore, A. Amador-Arjona, C. Farhy, C.-T. Huang, H. Kornblum, A. Terskikh

This study shows BMP2/4 induces SOX2 degradation in glioblastoma propagating cells, leading to differentiation into glial cells and reduced proliferation.

bioRxiv · Feb 3, 2022 · PreprintCancer Biology

Generation of a molecular interactome of the glioblastoma perivascular niche reveals Integrin Binding Sialoprotein as a key mediator of tumor cell migration

Y. Ghochani, A. Sohrabi, S. D. D. Muthukrishnan, R. Kawaguchi, M. Condro, S. Bastola, F. Gao, Y. Qin, J. Mottahedeh, M. L. I. Arispe, N. Rao, D. R. Laks, L. Liau, G. Mathern, S. Goldman, , H. Kornblum

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

D. Yamashita, D. Botta, H. J. Cho, X. Guo, S. Ozaki, V. L. Flanary, I. Sirota, M. Gao, S. Yamaguchi, M. A. Nakano, F. Zhou, H. Zhou, T. Kondo, T. Kunieda, D. Crossman, , I. Nakano

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

S. Bastola, M. S. Pavlyukov, Y. Ghochani, N. Sharma, M. A. Nakano, D. Muthukrishnan, S. Y. Yu, M. S. Kim, A. Sohrabi, N. P. Biscola, D. Yamashita, K. Anufrieva, R. Kawaguchi, Y. Qin, S. K. Seidlits, , H. Kornblum

This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.

bioRxiv · Oct 12, 2020 · PreprintCancer Biology

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

D. Yamashita, V. L. Flanary, R. B. Munk, K. Sonomura, S. Ozaki, R. Kawaguchi, S. Suehiro, S. Bastola, M. S. Pavlyukov, S. Yamaguchi, M. A. Nakano, T. Kunieda, D. Hambardzumyan, T. Kondo, H. Kornblum, , I. Nakano

This study shows that aging reduces neuronal signaling in gliomas, but NAD+ and BDNF can reverse these effects, improving outcomes in older mice.

bioRxiv · Oct 10, 2020 · PreprintCancer Biology

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of malignancy and response

M. Masterman-Smith, N. A. Graham, E. Panosyan, J. Mottahedeh, E. E. Samuels, A. Nunez, S. H. Lim, T. Phillips, M. Choe, K. Visnyei, W. H. Yong, T. G. Graeber, M.-F. Lang, H. Kornblum, J. Sun

The paper uses single cell proteomic analysis to identify distinct signaling phenotypes in gliomaspheres, revealing EGFR and AKT/TORC1 signaling divergence and potential therapeutic targets.

bioRxiv · Jan 14, 2020 · PreprintCancer Biology

Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control.

M. Garrett, T. O'Shea, A. Wollenberg, A. Bernstein, D. Hung, B. Staarman, H. Soto, T. Deming, M. Sofroniew, H. Kornblum

This paper develops an injectable hydrogel to deliver paclitaxel for glioblastoma treatment, achieving high local concentrations and improved survival in mice, but tumor cells can still escape the treatment area.

bioRxiv · Jun 20, 2019 · PreprintBioengineering