Author

D. D. Binns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. A. Kalwat· 2 shared A. V. Huynh· 1 shared B. A. Posner· 1 shared B. Barylko· 1 shared D. M. Jameson· 1 shared F. Armoo· 1 shared G. Roy· 1 shared J. P. Albanesi· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

M. A. Kalwat

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Author profile →

3 papers

Recent·Most cited

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function

K. Rodrigues dos Santos, G. Roy, D. D. Binns, M. G. Grzemska, L. F. Barella, F. Armoo, M. K. McCoy, A. V. Huynh, J. Z. Yang, B. A. Posner, M. H. Cobb, M. A. Kalwat

This study shows that SW016789 induces transient ER stress and reduces beta cell function through calcium influx, without causing apoptosis.

bioRxiv · Mar 7, 2022Cell Biology

Differential mobility and self-association of Arc/Arg3.1 in the cytoplasm and nucleus of living cells

P. N. Hedde, B. Barylko, D. D. Binns, D. M. Jameson, J. P. Albanesi

This study uses fluorescence nanoimaging to show that Arc/Arg3.1 exists as monomers and dimers in the cytoplasm and is predominantly monomeric and more diffusive in the nucleus, moving freely between PML-NBs and nucleoplasm.

bioRxiv · Dec 2, 2021Cell Biology

α2-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling

M. A. Kalwat, Z. Huang, D. D. Binns, K. McGlynn, M. Cobb

This study shows that micromolar epinephrine inhibits BDNF-TrkB signaling in beta cells via Gi/o-dependent mechanisms, highlighting concentration-dependent effects on insulin secretion.

bioRxiv · Jun 29, 2020Cell Biology