K. McGlynn

The Cancer Testis Antigen Testis Specific Serine Kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors

This study shows TSSK6 is abnormally expressed in colorectal cancer and promotes oncogenic behaviors like invasion and growth.

The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection Factor

This study identifies HORMAD1 as a tumor-specific factor that protects replication forks and prevents genomic instability in lung adenocarcinoma.

α2-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling

This study shows that micromolar epinephrine inhibits BDNF-TrkB signaling in beta cells via Gi/o-dependent mechanisms, highlighting concentration-dependent effects on insulin secretion.

Sperm-specific COX6B2 Enhances Oxidative Phosphorylation, Proliferation, and Survival in Lung Adenocarcinoma

The paper identifies COX6B2 as a sperm-specific gene that enhances oxidative phosphorylation, proliferation, and survival in lung adenocarcinoma by hijacking sperm motility metabolism.

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

The paper identifies ZNF165 as a SMAD3 cofactor that enhances TGF-beta signaling in triple-negative breast cancer, promoting tumor growth and survival.

ERK2 phosphorylates the epigenetic regulator CXXC-finger protein 1 (Cfp1)

The paper identifies CFP1 as an ERK2 substrate involved in chromatin regulation and shows its role in modulating histone methylase activity through phosphorylation.

Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

This study identifies chromomycin A2 as a potent inhibitor of glucose-stimulated insulin secretion from pancreatic β cells through multiple mechanisms including Wnt signaling disruption and calcium influx suppression.