Author

B. A. Posner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Mohanakrishnan· 1 shared A. V. Huynh· 1 shared B. Wang· 1 shared C. L. Cervantes· 1 shared D. D. Binns· 1 shared D. G. McFadden· 1 shared D. Nijhawan· 1 shared E. Lin· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiochemistry

A. Mohanakrishnan

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3 papers

Recent·Most cited

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

T. P. Nguyen, M. Fang, J. Kim, B. Wang, E. Lin, V. Khivansara, N. Barrows, G. Rivera-Cancel, M. Goralski, C. L. Cervantes, S. Xie, J. M. Peterson, J. M. Povedano, M. I. Antczak, B. A. Posner, , D. Nijhawan

This study develops an inducible mismatch repair system to identify targets of orphan cytotoxins by screening for compound resistance mutations in engineered cell lines.

bioRxiv · Feb 21, 2023Biochemistry

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function

K. Rodrigues dos Santos, G. Roy, D. D. Binns, M. G. Grzemska, L. F. Barella, F. Armoo, M. K. McCoy, A. V. Huynh, J. Z. Yang, B. A. Posner, M. H. Cobb, M. A. Kalwat

This study shows that SW016789 induces transient ER stress and reduces beta cell function through calcium influx, without causing apoptosis.

bioRxiv · Mar 7, 2022Cell Biology

A high-throughput assay to identify robust inhibitors of dynamin GTPase activity

A. Mohanakrishnan, T. V. M. Tran, M. Kumar, H. Chen, B. A. Posner, S. L. Schmid

The paper develops a sensitive fluorescence assay to identify dynamin GTPase inhibitors and finds that existing compounds like Dynasore and Dyngo-4a do not inhibit basal activity.

bioRxiv · Jun 21, 2017Biochemistry