Author

M. A. Kalwat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. D. Binns· 2 shared J. Z. Yang· 2 shared K. McGlynn· 2 shared M. G. Grzemska· 2 shared M. H. Cobb· 2 shared A. V. Huynh· 1 shared B. A. Posner· 1 shared F. Armoo· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

D. D. Binns

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Author profile →

3 papers

Recent·Most cited

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function

K. Rodrigues dos Santos, G. Roy, D. D. Binns, M. G. Grzemska, L. F. Barella, F. Armoo, M. K. McCoy, A. V. Huynh, J. Z. Yang, B. A. Posner, M. H. Cobb, M. A. Kalwat

This study shows that SW016789 induces transient ER stress and reduces beta cell function through calcium influx, without causing apoptosis.

bioRxiv · Mar 7, 2022Cell Biology

α2-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling

M. A. Kalwat, Z. Huang, D. D. Binns, K. McGlynn, M. Cobb

This study shows that micromolar epinephrine inhibits BDNF-TrkB signaling in beta cells via Gi/o-dependent mechanisms, highlighting concentration-dependent effects on insulin secretion.

bioRxiv · Jun 29, 2020Cell Biology

Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

M. A. Kalwat, I. H. Hwang, J. Macho, M. G. Grzemska, J. Z. Yang, K. McGlynn, J. B. MacMillan, M. H. Cobb

This study identifies chromomycin A2 as a potent inhibitor of glucose-stimulated insulin secretion from pancreatic β cells through multiple mechanisms including Wnt signaling disruption and calcium influx suppression.

bioRxiv · Jul 10, 2018Cell Biology