M. H. Cobb

The Cancer Testis Antigen Testis Specific Serine Kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors

This study shows TSSK6 is abnormally expressed in colorectal cancer and promotes oncogenic behaviors like invasion and growth.

ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers

This study identifies the ASCL1-DUSP6-ERK1/2 axis as a mechanism promoting survival in neuroendocrine lung cancers, suggesting DUSP6 as a potential therapeutic target.

Small molecule-mediated insulin hypersecretion induces transient unfolded protein response and loss of beta cell function

This study shows that SW016789 induces transient ER stress and reduces beta cell function through calcium influx, without causing apoptosis.

WNK1 Enhances Migration and Invasion in Breast Cancer Models

This study shows that inhibiting WNK1 reduces migration, invasion, and metastasis in breast cancer models.

A pressure sensing protein kinase

This paper identifies WNK3 as a direct hydrostatic pressure sensor, showing pressure-induced dimer-to-monomer transition and activation in D. melanogaster.

ERK2 phosphorylates the epigenetic regulator CXXC-finger protein 1 (Cfp1)

The paper identifies CFP1 as an ERK2 substrate involved in chromatin regulation and shows its role in modulating histone methylase activity through phosphorylation.

Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

This study identifies chromomycin A2 as a potent inhibitor of glucose-stimulated insulin secretion from pancreatic β cells through multiple mechanisms including Wnt signaling disruption and calcium influx suppression.