Author

C. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Baron· 3 shared C. Capelle· 3 shared D. Coowar· 3 shared M. Ollert· 3 shared N. Zeng· 3 shared R. Balling· 3 shared D. Brenner· 2 shared F. Q. Hefeng· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

A. Baron

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DJ-1 depletion slows down immunoaging in T-cell compartments

N. Zeng, C. Capelle, A. Baron, S. Cire, C. Leonard, D. Coowar, H. Koseki, A. M. Westendorf, J. Buer, D. Brenner, R. Krüger, R. Balling, M. Ollert, F. Q. Hefeng

This study shows that DJ-1 depletion delays immunoaging in T-cell compartments in both humans and mice by preserving non-senescent T cells and affecting hematopoietic and naive-CD8-intrinsic mechanisms.

bioRxiv · May 21, 2021Immunology

FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells

N. Zeng, M. Theresine, C. Capelle, N. Patil, C. Masquelier, C. Davril, A. Baron, D. Coowar, X. Dervillez, A. Poli, C. Leonard, R. Balling, M. Ollert, J. Zimmer, F. Q. Hefeng

This study shows that FAM13A depletion increases KLRG1 and reduces IFN-gamma production in NK cells, leading to increased lung metastases in a mouse model.

bioRxiv · Aug 26, 2020 · PreprintImmunology

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis

E. Danileviciute, N. Zeng, C. Capelle, N. Paczia, M. A. Gillespie, H. Kurniawan, D. Coowar, D. Vogt-Weisenhorn, G. Gomez-Giro, M. Grusdat, A. Baron, C. Guerin, D. G. Franchina, C. Leonard, O. Domingues, , F. Q. He

This study shows PARK7/DJ-1 enhances PDH activity in Tregs by inhibiting PDHA phosphorylation, maintaining Treg homeostasis and reducing EAE severity.

bioRxiv · Dec 20, 2019Biochemistry

The role of chromosomal inversions in speciation

Z. Fuller, C. Leonard, R. Young, S. Schaeffer, N. Phadnis

This study reconstructs the evolutionary history of chromosomal inversions in D. persimilis and D. pseudoobscura, showing that inversions segregate before speciation and contribute to hybrid incompatibilities.

bioRxiv · Nov 24, 2017Evolutionary Biology