Author

D. J. Pappin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. A. Tuveson· 2 shared K. D. Rivera· 2 shared K. Rivera· 2 shared T. E. Oni· 2 shared A. T. Yu· 1 shared B. A. Garcia· 1 shared B. Alagesan· 1 shared B. Liu· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

D. A. Tuveson

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5 papers

Recent·Most cited

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition

S.-H. Lin, Y.-C. Lee, S.-C. Lin, G. Yu, M. Zhu, J. H. Song, K. Rivera, D. J. Pappin, C. J. Logothetis, T. Panaretakis, G. Wang, L.-y. Yu-Lee

This study shows that prostate tumor-induced stromal reprogramming produces Tenascin C, which promotes metastasis by inhibiting YAP/TAZ through 5{beta}1 integrin.

bioRxiv · Nov 8, 2021Cancer Biology

PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR

A. T. Yu, C. Berasain, S. Bhatia, K. Rivera, B. Liu, F. Rigo, D. J. Pappin, D. L. Spector

The paper identifies PHAROH, an lncRNA overexpressed in hepatocellular carcinoma, which regulates c-Myc translation by sequestering TIAR, impacting cell proliferation and migration.

bioRxiv · Mar 23, 2021Cancer Biology

Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer

D. K. Cheng, T. E. Oni, Y. Park, J. S. Thalappillil, H.-c. Ting, N. Prasad, B. Alagesan, K. D. Rivera, D. J. Pappin, L. Van Aelst, D. A. Tuveson

This study identifies RSK1 as a KRASG12D-specific interactor in PDAC and shows RSK1 mediates negative feedback on wild-type KRAS.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

T. E. Oni, C. Bautista, J. R. Merrill, J. A. C. M. Goos, K. D. Rivera, K. Miyabayashi, G. Biffi, L. Garcia, D. Plenker, H. Patel, E. Elyada, M. Samaritano, K. H. Yu, D. J. Pappin, M. G. Goggins, , D. A. Tuveson

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

bioRxiv · Sep 10, 2020 · PreprintCancer Biology

HYPERsol: flash-frozen results from archival FFPE tissue for clinical proteomics

D. M. Marchione, I. Ilieva, B. A. Garcia, D. J. Pappin, J. P. Wilson, J. B. Wojcik

HYPERsol enables efficient and reproducible proteome analysis from FFPE tissues, achieving results comparable to flash-frozen samples.

bioRxiv · Aug 27, 2019 · PreprintCancer Biology