Author

S.-H. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 1 Ecology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:mouse· 5 Assay:proteomics· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

C. J. Logothetis· 4 shared g. yu· 4 shared G. Wang· 3 shared J. H. Song· 3 shared M. Zhu· 3 shared A. K. Jain· 2 shared C. S. L. Mak· 2 shared J. Park· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

C. J. Logothetis

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Author profile →

9 papers

Recent·Most cited

Prostate cancer-induced endothelial-to-osteoblast transition generates an immunosuppressive bone tumor microenvironment

S.-H. Lin, g. yu

This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

Alendronate Conjugate for Targeted Delivery to Bone-Forming Prostate Cancer

J. Damasco, G. Yu, A. Kumar, R. C. Lirag, E. Whitley, S.-H. Lin, M. P. Melancon

This paper develops a Cy5.5-alendronate conjugate for targeted drug delivery to bone-forming prostate cancer metastases, showing enhanced bone targeting and reduced systemic circulation.

bioRxiv · Sep 26, 2022Biochemistry

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

A. Munoz, R. Urak, E. Taus, H.-J. Hsieh, K. Jin, S.-H. Lin, D. Awuah, V. Vyas, S. J. Priceman, M. Clark, S. Forman, X. Wang

This study shows dexamethasone enhances CAR T cell persistence and function by upregulating IL7R, improving anti-tumor efficacy in vivo.

bioRxiv · Aug 29, 2022 · PreprintImmunology

KDM4A promotes the progression of neuroendocrine prostate cancer

C. S. L. Mak, M. Zhu, X. Liang, F. Wang, F. Yuan, A. G. Hoang, X. Song, P. Shepherd, D. Liang, J. Suh, B. Pradhan, J. Park, M. Zhang, E. Metzger, R. Schule, , G. Wang

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

bioRxiv · May 14, 2022 · PreprintCancer Biology

Activation of retinoic acid receptor reduces metastatic prostate cancer bone lesions through blocking endothelial-to-osteoblast transition

G. Yu, P. G. Corn, P. Shen, J. H. Song, Y.-C. Lee, S.-C. Lin, J. Pan, S. K. Agarwal, T. Panaretakis, M. Pacifici, C. J. Logothetis, L.-y. Yu-Lee, S.-H. Lin

bioRxiv · Dec 22, 2021Cancer Biology

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition

S.-H. Lin, Y.-C. Lee, S.-C. Lin, G. Yu, M. Zhu, J. H. Song, K. Rivera, D. J. Pappin, C. J. Logothetis, T. Panaretakis, G. Wang, L.-y. Yu-Lee

This study shows that prostate tumor-induced stromal reprogramming produces Tenascin C, which promotes metastasis by inhibiting YAP/TAZ through 5{beta}1 integrin.

bioRxiv · Nov 8, 2021Cancer Biology

Prevalence, complete genome and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge, Terpios hoshinota

Y.-H. Chen, H.-J. Chen, C.-Y. Yang, J.-H. Shiu, D. Z. Hoh, P.-W. Chiang, W. S. Chow, C. A. Chen, T.-H. Shih, S.-H. Lin, C.-M. Yang, J. D. Reimer, E. Hirose, B. H. Iskandar, H. Huang, , S.-L. Tang

The paper identifies a novel cyanobacterial symbiont in the coral-killing sponge Terpios hoshinota, characterizes its genome and metabolic potential, and proposes a new genus and species.

Environmental Microbiology · Oct 27, 2021Peer-reviewedEcology

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

M. Zhu, R. Peng, X. Liang, Z. Lan, M. Tang, P. Hou, J. H. Song, C. S. L. Mak, J. Park, S.-e. Zheng, A. Huang, X. Ma, R. Chen, Q. Chang, C. J. Logothetis, , G. Wang

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

bioRxiv · Jan 24, 2021Cancer Biology

Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

H.-W. Chao, H. Lin, Y.-S. Huang, J.-M. Fustin, M. Doi, H. Chen, H.-H. Lai, S.-H. Lin, Y.-L. Lee, P.-C. King, H.-S. Hou, H.-W. Chen, P.-Y. Young

This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.

bioRxiv · Aug 23, 2020Pathology