Author

D. L. Silver

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Biology Disciplines

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Biochemistry· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

E. G. Y. Chew· 1 shared F. T. Torta· 1 shared J. N. Foo· 1 shared M. Chua· 1 shared M. M. Lian· 1 shared M. R. Wenk· 1 shared O. Stelmashenko· 1 shared P.-O. Berggren· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

E. G. Y. Chew

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1 paper

Recent·Most cited

Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

X. Zheng, Q. W. C. Ho, M. Chua, O. Stelmashenko, S. Muralidharan, F. T. Torta, E. G. Y. Chew, M. M. Lian, J. N. Foo, M. R. Wenk, D. L. Silver, P.-O. Berggren, Y. Ali

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

bioRxiv · Feb 28, 2021 · PreprintBiochemistry