S. Muralidharan

Life stage impact on the human skin ecosystem: lipids and the microbial community

The paper investigates how life stages affect the human skin microbiome and lipid mediators, finding microbial correlations with lipid profiles and cytokine production.

Characterizing heterogeneity along EMT and metabolic axes in colorectal cancer reveals underlying consensus molecular subtype-specific trends

The paper analyzes CRC subtypes to show how EMT and metabolic axes vary across CMS subtypes, revealing subtype-specific metabolic and mesenchymal correlations.

PROTEOMICS OF HYPOTHERMIC ADAPTATION REVEALS THAT RBM3 ENHANCES MITOCHONDRIAL METABOLISM AND MUSCLE STEM-CELL DIFFERENTIATION

This study identifies RBM3 as a key mediator of hypothermic adaptation in skeletal muscle myoblasts, showing it enhances mitochondrial metabolism and muscle stem-cell differentiation.

PD-L1 activity is associated with partial EMT and metabolic reprogramming in carcinomas

The paper identifies a link between PD-L1 activity, partial EMT, and metabolic reprogramming in carcinomas using transcriptomic data and single-cell RNA-seq.

Investigating the mechanistic role of painful self-experience in emotional contagion: an effect of auto-conditioning?

The paper investigates whether auto-conditioning, through auditory associations with pain squeaks, enhances emotional contagion in rodents, but finds no significant differences in fear responses across experimental groups.

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

This study maps phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis, showing a biphasic mesenchymal response during de-differentiation and metabolic shifts.

Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel Cell Carcinoma

This study investigates GPC3 expression in Merkel Cell Carcinoma (MCC) and finds it is more common in MCPyV-negative tumors and linked to worse patient outcomes.

Quantifying the patterns of metabolic plasticity and heterogeneity along the epithelial-hybrid-mesenchymal spectrum in cancer

The paper analyzes metabolic pathway associations with EMT status across cancer datasets, revealing both general trends and heterogeneity in metabolic plasticity.

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

This paper evaluates BOXR1030, a CAR T cell therapy co-expressing GPC3-targeted CAR and GOT2, showing enhanced T cell metabolism and improved antitumor activity in preclinical models.

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells

This study develops a mechanistic model showing how non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells arise through EMT dynamics and phenotypic plasticity, suggesting MET inducers as potential therapeutic targets.

Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

Long acyl chain ceramides govern cholesterol and cytoskeleton dependence of membrane outer leaflet dynamics

The paper investigates how long acyl chain ceramides affect membrane outer leaflet dynamics in different cell types by analyzing cholesterol and cytoskeleton interactions.