M. R. Wenk

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

This study shows that depleting cationic lipids in Enterococcus faecalis leads to adaptive lipid remodeling, including reduced PG, increased phosphorus-containing lipids, and altered fatty acid metabolism.

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis

The paper shows that diacylglycerol (DG) depletion from the inner nuclear membrane during mitosis in fission yeast drives nuclear envelope expansion through DG-to-PA conversion and glycerophospholipid synthesis.

Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

The composition and function of Enterococcus faecalismembrane vesicles

This study identifies and functionally characterizes membrane vesicles from Enterococcus faecalis, revealing unique lipid and protein profiles and their potential role in virulence.

The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis

This study identifies FasR as a regulator of lipid metabolism in Mycobacterium tuberculosis, showing its essential role in virulence and immune evasion.

Long acyl chain ceramides govern cholesterol and cytoskeleton dependence of membrane outer leaflet dynamics

The paper investigates how long acyl chain ceramides affect membrane outer leaflet dynamics in different cell types by analyzing cholesterol and cytoskeleton interactions.

Doubling healthy lifespan using drug synergies

This paper shows that combining drugs targeting multiple ageing pathways in C. elegans can double lifespan and improve healthspan, with potential for human applications.