Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches
M. M. Sperry, R. Novak, V. Keshari, A. L. Dinis, M. J. Cartwright, D. M. Camacho, J.-F. Pare, M. Super, M. Levin, D. E. Ingber
The paper identifies host tolerance mechanisms to bacterial infection using a Xenopus model and multi-omics analysis, finding that metal chelators and HIF-1 agonists enhance survival.
bioRxiv · Sep 30, 2021Immunology